The impact of radioactive iodine treatment on subclinical left ventricular dysfunction in patients treated for differentiated thyroid cancer: assessing the predictive value of presystolic wave

Objectives: Despite strong evidence regarding the impact of radioactive iodine (RAI) on hematopoietic, genitourinary, and gastrointestinal systems, its role in cardiovascular system needs to be clarified. We hypothesized that presence a presystolic wave could predictive for dysfunction subjects receiving RAI. Thus, we investigated differentiated thyroid cancer (DTC) patients with without RAI therapy after undergoing total thyroidectomy. Methods: Patients were included study within 1-5 years thyroidectomy or treatment. Participants divided into three groups as follows: first group DTC who received following (Group 1; n = 33), second did not receive 2; 34). The third age-matched underwent suspicion resulted benign pathologies was also selected 3; 37). All transthoracic echocardiography. assessed Doppler imaging left ventricular outflow tract. Results: Presystolic more common 1) compared Group 2 (those RAI) (90.9% vs. 61.8% respectively, p 0.003), prevalence 3 54.1%. Multiple logistic regression analysis revealed (OR: 4.922, 95% CI: 1.640 – 20.022, 0.004) independently associated 5-fold higher risk wave. Conclusions: is five-fold increase wave, proxy marker subclinical dysfunction.